This study is administered for the purpose of identifying the psychosocial variables associated with intermixed addiction in a sample of adolescents and its relation to the desire of self-destruction. The study also drives at setting a future conception of encountering intermixed addiction in adolescents; identifying as well the role of environment and mass media in restricting such crucial phenomenon. The study sample consists of two groups, the first group contains (30) one-abuse substance addicts and the second group consists of (30) multiple abuse substance addicts. The researcher uses (7) main tools in study: Data Collection Form of (demographic variables of addict)- Standards Of Intermixed Addiction – Scale of Self-destruction – Scale of Cognitive Distortions of Addict – Scale of Maladjustment by researcher, in addition to personal interview. The study comes to multiple results which most significant are: There exists a reverse correlation between psychological variables associated with intermixed addiction and desire of self-destruction, since the coefficient correlation values among those addicts to one drug abuse is (-0.383) and (-0.595) for those with one drug abuse which are significant at (0.05). There is also a reverse correlation between psychological variables associated with intermixed addiction and desire of self-destruction for the full sample, since the coefficient correlation values are (-0.464) which are significant at (0.05). The study recommends focusing on the critical role of family for children for being the source of socialization, care, emotional safety, security, and stability; being thus the main axis in addiction's discourse that the unsettled family has negative impacts on children. Family is the institution grants love and psychological stability to children so it contributes building up balanced and far from tension and disorders personality of children; unlike the dissociated family which children are suffering from missed emotional and psychological background. It also recommends the necessity of following up school by family for checking out any change in children behavior or academic achievement before falling down a victim in addiction cycle.