Background: Tobacco use disorders associated with most psychiatric and respiratory disorders smoking ultimately destroy a person's life, rehabilitation and smoke cessation program can save the person's life. Aim Of The Work: assessment of rehabilitation and smoking cessation program and to evaluate the improvement of the patients after following the rehabilitation program. Patients And Methods: This is interventional study was carried on 120 patients collected from the private psychiatric clinicsas a convenience sample selection 120 are tobacco use disorder and had psychiatric disorder. Results: After one year of actual rehabilitation and smoking cessation program show improvement in clinical picture of patients Conclusion: Smoking cessation is associated with improved quality of life compared with continuing to smoke Recomendation: strict regulation should be adopted to prevent mal usage of smoking that lead to dependence and abuse also recommend that future policies should encourage further research into adverse health effects of smoking and the benefits of rehabilitation and smoking cessation.