The current study drives at identifying the relationship between psychological RESILIENCE and quality of life in a sample of adolescents who have lost one of their bodies' members, regarding (sex-age-adolescents' education- parents' monthly income), (child's existence inside/outside care houses), and amputation cases in lower limbs (one limb – two limbs). The study significance is reflected in the global concern in children and adolescents in general, and those with disabilities because of amputation of one of their limbs in particular. The study sample is consistent of (130) male/female adolescents, losers of one of their lower limbs who live in Cairo. The sample is selected from Al-Orman Society and Kasr El-Einy hospital. Results indicate that there is a significant correlation between psychological RESILIENCE and quality of life in the sample of both males and females at significance level (0.000) for females and (0.002) for males; with coefficient correlation (0.340) for males and (0.616) for females. There is a positive correlation between full scale of psychological RESILIENCE of disabled adolescents and full scale of quality of life at significance level (0.000) and coefficient correlation value (0.412) regarding the relationship between illiterate people, primary, and preparatory education people. The study recommends that the state competent bodies, organizations, institutions, and governmental and non-governmental organizations should contribute considering with amputated limbs individuals, particularly, adolescents, and providing more habilitated schools suitable for conditions. The study also recommends parents either fathers or mothers to care their children psychologically, assisting their children to overcome this dilemma and encourage them to join their children to that kind of schools.