We aim in this research to evaluate the role of screening of women for exposure to environmental estrogens and to determine its predictive value for early detection of cancer breast.Recognition of the potential harmful effects related to cancer breast, may facilitate screening, and early detection of cancer breast.Fifty adult women with breast cancer who were referred to the radiology department were included as the study group. The cases were compared to control group of fifty women who were referred to the radiology department for routine screening for breast cancer and had no breast complaint or abnormalities detected.All women in both groups were subjected to a comprehensive structured questionnaire including the following:  age, residency, marital status, parity, occupation, breast feeding, family history, age of menarche, age at menopause, hormone replacement therapy, contraceptive pills/injections, applications of cosmetics (body lotion, cream, make up, foundations, perfumes), wearing bras, implant, use of plastic wrappings, use of bottles/foams, dietary habits (fast/fresh food), chest irradiation, complaint of women (breast mass, pain, nipple discharge, skin discharge), history of exposure to other possible risk factors such as smoking, exposure to chest irradiation, radon, asbestos, pesticides and children toys. The collected data were organized, tabulated and statistically analyzed using statistical package for social science, version 16.Results were a significant relationship was found between incidence of breast cancer and exposure to cosmetics, smoking, physical inactivity, frequent fish consumption and low fruit intake.Exposure toxenoestrogens (e.g., insecticides, food preservatives) was a serious factor to breast cancer incidence.Some environmental factors showed rather insignificant relationship with exposure to radon or asbestos, wearing bra, or plastic use to incidence of cancer breast.Conclusion wasBreast cancer has currently no available cure so perhaps the best strategy to combat breast cancer perhaps relies on early detection and prevention through avoiding the exposure to high risk factors.