During the last three decades, many efforts have been made to protect tpopulations from harmful exposure to outdoor pollutants. However, people spend about 80-90% of their time in various indoor ambiences (i.e. homes, offices, restaurants, etc.) and the quality of indoor air is an important factor influencing human health .we measured indoor air pollutants levels in homes in Cairo-Egypt to estimate the different sources of pollutants and measured the concentration of following indoor air pollutants H2S,NO2,CO,SO2 and particulate in four residence areas two of them near industrial area which are Shoubra el khiema and Helwan ,the other two residence area were Heliopolis and Nasr city to use these data to estimate the health burden that is attributed to air pollution within homes, 30 sample were collected from 30 homes in each area using gas analyzer and particulate analyzer (Thermo dust meter).the analyses of the results demonstrated that there was a significant increase of CO, H2S, SO2, NO2 and particulate levels in industrial area with mean ±SD : 6.1±8.3, 0.05±0.01, 0.05±0.01, 0.2±0.09 and 0.3±0.04 respectively than non-industrial area with mean ±SD : 2.7±0.7, 0.01±0.07, 0.03±0.02, 0.1±0.02 and 0.2±0.03 respectively with p-value= 0.002, 0.0001, 0.0001, 0.002 and 0.002  respectively.