Recently the use of synthetic food coloring additives was increased and the levels of human exposure to such agents are very broad, thus feeding over long periods may continually possess potential hazards to the human health. Evaluation of the toxic effects of synthetic dyes Brilliant Blue, Tartrazine and Carmoisine were tested in rats by measuring their actions on renal, hepatic function, and body-weight gain. Rats were fed synthetic dyes supplemented diet, daily for 60 days orally in two doses, one low and the other high dose followed by serum sample collection for determination of urea, creatinine, uric acid, ALT, AST, ALP, glucose cholesterol, triglycerides and estimation of hemoglobin conc.
Our data showed a significant increase in cholesterol, triglycerides, ALT, AST, in addition to serum urea and creatinine levels in treated rats, while, they recorded a significant decrease in percentage of body weight change, and this significant change were more apparent in high doses than low doses.