Sustainable management of wetlands ecosystem become a serious crucial, especially with the rapid population growth and increase of anthropogenic activities, in addition to climate change threats. Several approaches have been introduced for ecosystem analysis and management since 1990s, where Driver – Pressure – State – Impact – Response (DPSIR) framework is one of the widely used approaches for assessing and managing environmental problems. This study applied DPSIR framework on Burullus wetland as a model of Egyptian Northern ecosystems, in order to analyze it from the perspective of its potential to deliver ecosystem services within current state of changes resulted from socio-economic drivers. Such changes have a direct or indirect impact on the wetland health and productivity, thus distress local communities relay on its services. Five main socio-economic drivers were analyzed and introduced through DPSIR framework. Number of actions and responses were recommended depending on DPSIR framework analysis. The results of this study will guide to prepare a management and restoration plan for Burullus wetland based on ecosystem approach.