Image de-noising is one of the main steps in the medical image analysis process. In medical imaging, noise usually occurs at the capture stage of medical machines such as the ultrasound machines. This noise may hide important information that affects the diagnosing process. Current medical image denoising techniques still need modifications to enhance their denoising capabilities, especially traditional parameter dependent techniques such as VisuShrink denoising technique. This technique has a threshold that needs to be adjusted to efficiently de-noise the images. In this paper, an intelligent framework is proposed to assign a threshold to VisuShrink technique based on the current image features. These features extracted from the image using Scale Invariant-Feature Transform (SIFT) technique are used to train different machine learning (ML) techniques for predicting the appropriate threshold. The experimental results showed that the proposed framework managed to reduced the noise compared to VisuShrink technique applied using a fixed threshold.