A total number of 25 V-line rabbit does aged 8-9 months and weighed 3381 g ±5.575 were used in this study. Animals were distributed randomly into five experimental groups of 5 does each. The first group fed the basal diet ad libitum and served as a control. The second and third groups were fed the basal diet supplemented with 1.0 and 1.5% pomegranate peel powder (PPP) in the diet, respectively. The fourth and fifth groups were fed the basal diet supplemented with 1.0 and 1.5% pomegranate peel extract (PPE) in the drinking water, respectively. The results revealed that does supplemented with PPE at different levels significantly consumed (P≤0.05) more feed compared with does supplemented with different levels of PPP or control group during experimental period. Pregnant rabbit does supplemented with 1% PPP recorded (P≤0.05) more litter size at day 28^th (at weaning age) than control group. Using dietary PPP or drinking PPE at different levels for pregnant rabbit does showed significantly (P≤0.05) higher litter weights at birth and at 7^th, 14^th and 21^st days of lactation period and at weaning compared to control does. Adding 1.5% PPP or 1% PPE for pregnant rabbits had significant (P≤0.05) lower pre- weaning mortality rate compared to other treatments and the control group. Adding PPP or PPE for pregnant rabbit had significant (P≤0.05) increasing milk yield at all studied ages compared to control does. From the present study, it could be concluded that using powder pomegranate peel in diet or it's extract in drinking water had a positive effect on V-line does performance which reflected in litter traits (litter size and litter weight), pre weaning mortality rate and milk yield.