The current study evaluated the effect of dietary inclusion of curcumin (Cur) or curcumin nanoparticles (CurNPs) on growth performance, blood metabolites, antioxidant status and humoral immunity of broiler chicks. In a completely randomized block design, a total of 504 one-day-old Ross-308 broiler chicks were randomly allocated to seven experimental groups with eight replications of nine birds each. The first (control) group received the basal diets without supplements while the 2nd, 3rd and 4 th groups were fed diets supplemented with 25, 50 and 100 mg.kg-1 of Cur and the 5th , 6 th and 7th groups were fed the same levels but from CurNPs, respectively. Results showed that the addition of 50 and 100 mg.kg-1 of Cur, irrespective of the form used, improved body weight, weight gain, feed conversion ratio and reduced feed consumption. The same doses increased relative weights of liver, thymus and bursa of Fabricius. Hypocholestrolimic impact of Cur and CurNPs was remarkably observed in treated birds. Regardless Cur form, lipid peroxidation was reduced while glutathione peroxidase and superoxide dismutase activities were enhanced in groups treated with 50 and 100 mg.kg-1 . Both Cur forms exhibited immunomodulatory effect as total serum antibody titer against SRBCs, IgG and IgM were elevated at 21 and 35 day of age. In conclusion, supplementation of Cur and CurNPs to broiler diets, particularly at levels of 50 and 100 mg.kg-1 , improved growth performance, reduced blood cholesterol, and enhanced redox status and humoral immune response of broiler chickens.