The experiment was carried out to evaluate the response of broilers fed diet supplemented with antibiotic alternatives, Probiotic (BioPlus 2B), Prebiotic (Techno MOs), Synbiotic and medicinal herbs (Mixture of Origanum majorana, Foeniculum vulgare and Carum carvi in ratio 1: 1: 1), on their performance and intestinal histology. A total of 125-day old chicks cobb (500) broiler chicks were randomly distributed into 5 treatments with five replicates of 5 chicks each and raised for 6 weeks. Chicks were kept in cleaned and fumigated cage of wire floored batteries. Experimental diets and water were offered ad-libitum over the experimental period starting from one day old. The experimental treatments received basal diets which were formulated to starter (1-21d) and grower- finisher (22-42d) broiler growth periods. During each growth period, birds received the control diet (un-supplemented), whereas the other groups fed diet contained either of tested feed additives (probiotic, prebiotic, synbiotic or medicinal plants mixture). The most important results obtained from this study could be summarized as follows: - a highly significant effect (p≤ 0.05) on live body weight at the end of experiment period was observed due to the effect of synbiotic treatment compared the other treatments. A highest body weight gain was recorded by the synbiotic treatment compared the control ones. Different feed additives improved feed conversion ratio compared to control (p≤0.001, for the whole experimental period. All supplements effect the intestinal histology compared to that of the control in duodenum and jejunum, intestine region but the effect is not significant. Also, feed additives led to significant improvement in villus height and crypt depth in ileum region.  In conclusion, results show that synbiotic treatment was the superior in improving productive performance of broilers. Further research is still need to verify current results.