A total number of three hundred and fifteen of 14 days old Muscovy ducklings were arrangement randomly into 7 experimental groups and allocated into three replicates. The experimental treatments were arranged in one way classification by using three sources of phytogenic plants being Moringa oleifera leaves meal (MLM), Rosmarinus officinalis leaves meal (RLM) and Olea europaea leaves meal (OLM) with two levels of plant addition (1or2%) compared to the commercial diet (control). Results showed the highest value of final live body weights (4185 g) was recorded for diet that supplemented with 1%MLM; while, the lowest weight recorded for diet supplemented with 2% OLM being 3507 g compared with control group. Feed intake (g/bird) decreased significantly for treatment groups compared with the control group. The best feed conversion was recorded by ducklings fed1%MLM compared with the control. The highest digestion coefficient of CP being 80.13% was achieved by the group fed 2%MLM vs. control (74.44%). Ducklings fed diet supplemented with natural additives recorded the highest values of edible giblets% and digestive tract length (cm) but lowest digestive tract weight % compared to the control group. Feeding diets contained 1%RLM,2%RLM and 1%OLM recorded highest values of overall acceptability of ducklings meat compared with the other experimental groups. The highest values of albumin (g/dl) and albumin/globulin ratio were recorded by the groups fed natural feed additives compared to the control group; while the lowest triglycerides value was for the ducklings fed 2%OLM being 250 g/L. Natural feed additives did not affect liver function or kidney function, while; values of total anti- oxidants capacity were significantly increased .Experimental groups fed 1% MLM, 2%MLM, 1%RLM or 1%OLM recorded the highest economic efficiency. It could be concluded that, the use of natural feed additives in Muscovy ducklings diets improved growth performance, increased immune response and improved economic efficiency.