The objective of this study was to investigate the effects of using natural and synthetic antioxidants for improving growth performance, some blood parameters, manure characteristics and economical efficiency. A total number of 360 Ross breed chicks, two day old, were weighted and randomly distributed into six groups each of sixty birds; each group has three replicates each replicates has 20 birds which were allocated in individual pin. The experiment was approved at the same time following similar design. Feed and water were provided ad libitum. The experimental groups were arranged as the following: T1: (positive control),commercial diet, received a 23% crude protein (CP), starter, and 20% CP (grower), according to the breed requirements, without additives; T2: (negative control) received a 20% CP (starter) and 17% CP (grower) without additives; T3: negative control + 0.15g butylated hydroxyl toluene (BHT)/ kg diet; T4: negative control + 3g pulicaria undulata powder/ kg diet. Results showed that: increasing feed intake, body weight and body weight gain at group T4 at 36 days. Also, group T4 at 36 days old was significantly (P < 0.05) the best feed conversion ratio (FCR) compared to T2 group. Group T4 at 36 days old was significantly (P < 0.05) the best values of total protein (TP), albumen (A), globulin (G), A/G ratio, total antioxidant capacity (TAC),glucose (Glu) and triglyceride TG. Also, T4 significantly (P < 0.05) achieved the best values of % nitrogen (N) reducing compared to positive control. From economical point of view, it can be concluded that negative control + 3g pulicaria undulata powder/ kg diet (T4) value for chicks could be recommended for releasing best results of performance.