It is assumed that pregnant rabbits under heat stress condition need to be supplemented with an antioxidant substance that help to keep pregnant does healthy. Various antioxidants are available in the natural like pomegranate peel (PP). The purpose of the current study is to understand the effect of different levels of pomegranate peel supplementation on the hematological and antioxidant status of heat-stressed doe rabbits pregnant at 21st day. Thirty-two V-line does were divided into 4 treatment groups (8 does/group): control, pomegranate peel (0.75%, 1.5% and 3.0%). All treatment diets were free of any antibiotics or added antioxidants. Rabbitry minimum and maximum ambient temperature, humidity and temperature-humidity index throughout the experimental period were between 27.5-33.5°C, 64-76% and 77.84 -87.77, respectively. Significantly, all diets containing PP improved each of serum total antioxidants capacity, high density lipoprotein, high density lipoprotein/low density lipoprotein ratio and significantly reduced low density lipoprotein, malondialdehyde and cholesterol concentrations. Pomegranate peel at 3% inclusion level significantly recorded the highest count of red blood cell. Likewise, the two highest level of pomegranate peel (1.5 and 3%) recorded the highest concentration of hemoglobin. The present results indicate that the supplementation of diets with natural antioxidants as pomegranate peel is necessary to overcome some side effects of heat stress on pregnant does via enhancing their antioxidant status and modulating lipids metabolism during the 3rd trimester of pregnancy.