This study was conducted to evaluate the effect of selection on the productive performance of local chicken line, Giza M-2 line, after 5 generations of selection for increasing 6-week live body weight (LBW). The performance of Giza M-2 and Random Bred Control (RBC) lines; LBW, LBW at sexual maturity (BWSM), egg number (EN), egg weight (EW), and first egg weight (FEW) were evaluated at the 3rd (G3), 4th (G4), and 5th (G5) generations. The Random Bred Control line (RBC) was used as a control group. The results could be summarized as follow: There was significant improvement in 6-week LBW for Giza M-2 line from one generation to the next. The difference between Giza M-2 line and RBC line was 358 g after five generations of selection for increasing 6-week LBW. Also, females of Giza M-2 line had significantly higher BMSW, EN, EW, and FEW with comparison to the RBC line for all generations. In conclusion, there was positive response in LBW and egg productive performance in Giza M-2 line associated with our breeding program. Also, selection in Giza M-2 line may had large impact on frequency of genes controlling economically important traits, such as LBW and reproduction. In Giza M-2 line, future generations, to achieve proper meat production, we will focus on genetic selection of traits relevant to modern broiler breeding.