Arbor Acres broiler chickens (n=140), 7-day-old, were used in a straight-run complete randomized experimental design. The broilers were distributed among four treatment groups with five replicates per treatment and seven chickens per replicate. During the experimental period (7-42 day-old), the chickens were fed iso-caloric and iso-nitrogenous diets with ginger (Zingiber officinale) level of 0.5% given either continuously or intermittently (two treatments), mannanoligosaccharide (MOS) of 0.05%, and the unsupplemented control. The objective of this study was to study the response of broiler chickens to continuous or intermittent supplementation with ginger as phytogenic additive compared with MOS on performance and cost of supplementation. The intermittent treatment was given as two days per week. Feeding 0.5% ginger resulted in higher body weight gain (BWG), European production efficiency factor (EPEF) and economic efficiency (EE) than MOS, however, feed conversion ratio (FCR) was similar among different experimental groups. Ginger level of 0.5% continuously decreased serum aspartate aminotransferase (AST), increased serum globulin, and 0.5% ginger intermittently increased antibody titer to Newcastle disease virus (NDV). Ginger given continuously or intermittently significantly decreased meat lipids and plasma glucose with intermittent supplementation showed stronger effect on meat lipids than continuous supplementation. Hence, it could be concluded that 0.5% ginger given continuously can replace MOS as a prebiotic without negative effects on productive performance, carcass traits, meat quality, blood constituents and immune response as compared with the control and this warrant further investigation.