Effect of replacing yellow corn (YC) by distillers dried grains with Solubles (DDGS) was studied on Japanese quail chicks performance. One hundred and eighty unsexed one- day old chicks, distributed at random equally into 3 groups each in 3 replicates. Treatments were: control with 0% DDGS, T1 containing 50% of YC as DDGS and T2 containing 100% of YC as DDGS. The experiment lasted for 42 days and all chicks had free access to feed and water. Average feed intake (FI), daily gain (BWG) and feed conversion efficiency (FCR) were determined. Data showed that, chicks fed100 % and 50% of YC as DDGS had higher BWG at 42 days, higher FI and better FCR compared to the control diet. Also, T1 and T2 had the highest globulin concentrations and total plasma protein, than the control diet. No significant effect of DDGS levels on carcass characteristics. Digestibility of crude protein was affected significantly (p<0.05) with increasing DDGS level. In conclusion, use of DDGS at 100% of YC showed the higher results compared to the other treatments. Therefore, DDGS could be successfully replaced 100% of YC in diet of Japanese quail.