Countries having shortage in animal protein, such as Egypt can depend on intensive production of quail to compensate a part of this shortage. So, the present study was carried out at Poultry Farm, Faculty of Agriculture, New valley Branch, Assiut University, Egypt, to study the effect of different levels of yeast and supplementation of Hafsh (nonedible dates produced from dates factories) on performance and some physiological parameters as well as meat quality of Japanese Quail (Coturnix japonica). A total of 270 chicks, one week old unsexed Japanese Quails were weighed andrandomly assigned to 9 groups housed in 3 replicate pens with 10 birds in each. Nine different treatments in a 3 x 3 factorial arrangement including three levels of yeast (0.0, 0.5, 1.0 g yeast /L) in drinking water with three date residues levels (0, 5 and 10% ) supplemented into diets. The obtained data pointed out that the yeast level,hafsh levels and interactions between yeast level and hafsh level had a significant effect on growth performance (body weight, feed intake , body weight gain and feed conversion ratio), where there were growth performance of quail inhanced, and some internal members ratios in relation to live bird weight of Japanese Quail except spleen ratio was insignificant . Results showed that different treatments of yeast or date residues alone or with yeast at any level remark that significant (p<0.05) difference in some blood hematological ,biochemical parameters (total protein , albumin , total lipids , cholesterol and glucose concentration), liver function (AST and ALT), physical properties, chemical composition and sensory evaluation of breast and thigh muscles of quail meat. The counts of total aerobic and anaerobic bacteria and total coliform of chick intestinal were decreased due to add different treatments compared with the control . From the present work , it may be concluded that the application of 1.0g yeast/liter ( in water) with 10% hafsh (in feed) improved growth performance, some physiological parameters, carcass weight and nutrients digestibility, dressing%, breast weight%, thigh weight%, meat quality of Japanese Quail and is advisable.