This study was designed to investigate the effect of adding combination of Mannan Oligosaccharide and β_Glucans (Agrimos) in diet on productivity and immunity level of does and follow this effect of adding on growing rabbits. At the first experiment: A total of 64 V-Line Does at 5 months of age with an average body weight    (3.4± 0.23) Kg divided randomly into 2 treatment groups (n =32 does per group) which received two experimental diets (the basal diet for control group and 2 kg Agrimos /Ton basal diet for treatment group). At the second experiment: From the third parity at 4 week of ages a total number of 108 unsexed weaned V- Line rabbits which produced of each group does (control and treatment does) from the first experiment, was divided into three equal groups each group consisted of 36 rabbits (1^st group was fed a basal diet and served as control; 2^nd group was fed a basal diet with 1kg Agrimos/ ton and 3^rd group was fed a basal diet with 2kg Agrimos/ ton.). Results of the current study are summarized as follows: The does which fed diet contained 2 kg Agrimos /Ton basal diet for treatment group recorded higher litter size at birth (10.41) than its fed basal diet (9.44) with significant differences. Also, the corresponding values of bunny number at weaning were (7.19) higher than its (6.62) but without significant differences.    Also, the treated does (2 kg Agrimos /Ton basal diet) resulted in increases of white blood cells (WBC*10³), lymphocyte, Mid and IgG comparing with control does (8.98*10³, 52.59%, 10.82% and 691.39 mg/ml vs 8.29*10³, 44.55%, 10.16% and 597.75 mg/ml, respectively). These results indicated that improving of immunity level for treated doe rabbits by adding Agrimos in diet.Mean of body weight gain from 4 to 10 wks of age for growing rabbits which producing of treated does (1253.53 g/2wks/rabbit) had higher growth than its producing of control does (1076.60 g/2wks /rabbit) with significant differences. Also, the highest body weight gain from 4 to 10 wks of age (1292.00 g/2wks/rabbit) was obtained of fed 1 kg Agrimos/ ton basal diet for growing rabbits producing of treated does during the period of weaning to 10 wks of age. Means of white blood cells (WBC*10³), lymphocyte and Mid for growing rabbits which producing of treated does (9.83*10³ , 46.49% and 11.53%, respectively) were higher values than its producing of control does (9.15*10³, 42.87% and 10.81, respectively). In conclusion, adding Mannan Oligosaccharide and β_Glucans (Agrimos) in rabbits diets significantly improved litter size at birth and immunological status of doe rabbits. And also, body weight gain from 4 wks to 10 wks and immunological status of growing rabbits.