Purpose: The present study was performed to evaluate the bond strength of EndoSeal MTA and AH Plus after using EDTA or apple vinegar as final irrigant. Materials and Methods: Sixty extracted human single rooted teeth were decapitated, instrumented using Universal ProTaper rotary system up to size F4 and divided randomly into two main groups (n=30) according to the solution used as final irrigation; Group I: irrigated with 17% EDTA and Group II : 5 % Apple vinegar, then distributed according to sealer used in obturation with gutta-percha into four subgroups (n=15); subgroup IA (EDTA + AH Plus), subgroup I B (EDTA +Endoseal MTA), subgroup IIA (apple vinegar + AH Plus), and subgroup IIB (apple vinegar + Endoseal MTA). After obturation and incubation in 100% humidity at 37°C for one week. All roots were embedded in self cure acrylic resin and sectioned horizontally into slices of 2 mm thickness, the push- out test was applied using universal testing machine, bond strength (MPa) calculated and the data were tabulated and statistically analyzed. Results: AH Plus represented the highest bond strength after using EDTA or apple vinegar compared with Endoseal MTA, EDTA showed superior results with both types of sealer compared to apple vinegar, and the middle part of the root canal showed the highest bond strength (P<0.05) Conclusion: EDTA final irrigating solution reported higher values of the bond strength compared to apple vinegar with both AH Plus and Endoseal MTA, and AH Plus reported highest push-out bond strength with both irrigating solutions