Purpose: This study was designed to evaluate implant stability in partially edentulous patients by investigating the effect of systemic simvastatin administration on the bone regeneration around the dental implant. Patients and Methods: A total of 18 patients were divided into two groups. Group I:9 healthy patients underwent a one-stage titanium screw-type endosseous dental implant and Group П:9 patients on simvastatin therapy (20 mg daily) as a prophylaxis drug, underwent the same type of one stage titanium screw type of endosseous dental implant as the control group. Modified plaque index (MPI), Probing depth (PD) and Modified Gingival Index (MGI) were recorded. Implant stability was recorded immediately and after 6months. Results: Group II showed a higher mean implant stability (79.14±4.38) than group I (72.86±11.41) at 6 months with a non-significant difference Also, there is a nonsignificant difference of MPI, MGI, and PD between both groups after 3 and 6 months respectively. Conclusion: Simvastatin group showed higher implant stability than the control group. Simvastatin might have the ability to assist and enhance the osseointegration procedure for bone surrounding the dental implant.