Purpose: This study compared between nano composite denture teeth and IPN cross-linked acrylic teeth regarding masticatory efficiency and some mechanical properties (wear, micro tensile bonding strength to denture base). Material and methods: Ten completely edentulous patients with ages ranging from 55-60 years were selected. Each patient received two dentures made from heat-cured acrylic resin , One with IPN cross-linked acrylic teeth and the other with nano composite teeth. Masticatory efficiency was evaluated for each patient at the time of insertion of the dentures and one month later. Laboratory study: For testing wear, thirty specimens were constructed and divided into two groups. Fifteen IPN cross-linked acrylic teeth (Group І) and Fifteen nano composite denture teeth (Group ІІ). For testing Micro tensile bonding strength, Twelve specimens were constructed of artificial teeth together with the heat-cured acrylic resin bases, These specimens were fixed to a micro- sawing machine and cut into one hundred and twenty micro beam samples which were then divided into two groups; sixty beams of IPN cross-linked acrylic teeth (Group І) and sixty beams of nano composite denture teeth (Group ІІ). Results: The results revealed no statistical significant differences (p ≤ 0.05) as indicated by paired t-test between IPN cross-linked acrylic teeth and nano composite teeth in masticatory efficiency, wear, and micro tensile bonding strength to the denture base. Conclusions: In comparison to IPN cross-linked acrylic teeth, nano composite denture teeth showed non-significant difference regarding masticatory efficiency, wear resistance, and micro tensile bonding strength to the denture base.