Purpose: A comparative evaluation of Aloe Barbadensis plant extract and Mineral Trioxide Aggregate as pulpotomy agents in primary molars. Materials and methods: Thirty eight Children, aged between 4 to 8 years old of both sexes, 20 girls and 18 boys were included in this study. Pulpotomy was made in primary molars, it was divided into two groups. The first group included 32 teeth indicated for pulpotomy with NeoMTA and the second group included 32 teeth indicated for pulpotomy treated with Aloe vera .Clinical and radiographic follow up were made for each child after 1,3 and 6 months. Results: NeoMTA showed higher clinical success results than Aloe vera after 3 and 6 months,Chi square test shown a significant difference statistically between groups in all of its clinical findings and in the overall clinical and radiographic success 6 months after treatment. Conclution: Upon comparison between Aloe vera and NeoMTA as a pulpotomy medications NeoMTA showed better results clinically and radiographically.