Purpose: The purpose of this study was to access post-operative clinical as well as radiographic success of Mineral Trioxide Aggregate (MTA), Diode Laser and Antioxidant mix as pulpotomy agents for human primary molars. Materials and Methods: A total of 60 primary molars that had deep carious lesion and need pulpotomy treatment from 38 healthy and cooperative patients, aged 5-8 years old were chosen for this study. After removal of the coronal tissue and depending on the type of radicular pulp medicament, the teeth were divided randomly and equally into three groups; Group I (MTA), Group II(Diode Laser) and Group III (Antioxidant mix). Treatments in all groups were completed with Glass Ionomer restoration then stainless steel crowns. Results: The cumulative clinical and radiographic success rates after 6 months follow up were 100%, 90% and 85% for the MTA, Diode Laser and Antioxidant mix pulpotomy groups respectively. Conclusion: MTA, Lasers and Antioxidant mix used for primary teeth pulpotomy had a more advanced success rate on follow-up. Statistically, no significance difference was found between the three study groups in the overall clinical and radiographic success rate.