Purpose: The current study aimed to asses shear bond strength of Vita Suprinity ceramics bonded to dentine and enamel utilizing three different types of resin cements. Materials and Methods: Sixty ceramic samples (Vita Suprinity) were divided according to the tooth substrate into two equal groups (thirty samples cemented to enamel substrate and thirty samples to dentine substrate). Each group was divided into three subgroups (n=10) according to cementation mechanism: SubgroupI; Etch &rinse mechanism (Duolink resin cement. All bond universal and acid etch), SubgroupII; Self etch mechanism (Bifix QM resin cement and futura bond) and subgroupIII; Self- adhesive mechanism (Relyx Unicem). The cemented specimens were thermocycled then shear bond strength was measured. Results: By comparing cementation protocols the total etch mechanism recorded the highest bond strength while the self- adhesive mechanism recorded the lowest strength. Comparing substrates, the enamel results were significantly higher than that of dentine results. Conclusion: Although the self etch and self-adhesive resin cements are simple in manipulation, their bond strength is lower than that of total etch technique so they need improvement.