Purpose: to compare the efficiency of tissue expander versusthe platelet rich fibrin (PRF) in closure of secondary palatal fistula (PF). Patients and Methods: a prospective comparative study with 3 follow-ups (FU) at 1, 3 weeks, and 6 months was undertaken in 2 groups. Patients from Group I (GI) received tissue expander at the 1stsession for expansion of oral mucoperiosteum; the expanded palatal mucosa was used in the 2nd session as 2ndoral layer, while group II (GII) in which PF was closed in 1session by nasal layer then PRF as a substitute for oral layer. Results: GI showed good results regarding measurements of surface area SA of defect at 6 months and better outcome withGII regarding to the clinical healing score at 7, 15 days. Conclusion: Based on the limited size study we concluded that the methods of using either self-inflating tissue expander or PRF are available alternatives. However in both groups not all the cases showed completePF closure and further studies are needed to confirm the success of these techniques.