Purpose: This study aimed to evaluate strain induced in implants supporting fixed detachable prosthesis with different implant protocols using strain gauge analysis. Material and methods: This stress analysis study used two 3D models simulating a completely edentulous lower arch to support and retain fixed detachable prostheses. In the first model four implant beds were considered; two anterior implants oriented axially and two posterior implants placed at the premolar region tilted 30 degrees. In the second model implant beds were designed with two anterior implants oriented axially and two short posterior implants 8 mm length placed in the first molar region oriented axially. Standardized static load was applied unilaterally by using a loading device (universal-testing machine). Strain gauge was used to measure strains induced in each implant. Results: Regarding the loaded side: Strain induced in the anterior implant and in the lingual and distal aspect of the posterior implant in the first model has shown higher strains compared to the second model. This difference was statistically insignificant in the anterior implant and in the lingual aspect of the posterior implant, while strains induced in the distal aspect of the posterior implant was statistically significant higher in the first model compared to the second model. Conclusion: With the limitation of this in vitro study, it can be concluded that short implants induce less stresses distally than tilted implants.