Purpose: The present study was carried out to evaluate and compare the clinical effect in a short term of three conservative treatment methods for myofascial pain disorder syndrome (MPD): pharmacotherapy, inter occlusal splint and low level laser therapy (LLLT). Subjects and Methods: The present study was applied on thirty (n=30) females patients which suffered from myofascial pain disorder syndrome (MPD).They were selected for this study with age ranged from 17-45 years. Patients were divided equally and randomly into three groups; Group I : were treated by LLLT, Group II were treated by oral appliance therapy and Group III were treated by pharmacotherapy. The outcome variables were pain score and the maximum interincisal opening (MIO). Pain score was assessed by using Visual Analogue Scale (VAS); both variables were assessed preoperatively, postoperatively at the first month weekly, three months, and six months. Results: VAS scores decreased and MIO increased gradually throughout the follow up durations at first, third, and six months after treatment in all groups (P < 0.05). Although there was a difference between groups I, II and III, however, the difference was not statistically significant. Conclusions: low level laser therapy can be considered as a suitable and non-invasive treatment alternative for MPD. Also it was effective, had showing promising results and can be used as treatment of MP. LLLT shows its effects in a short term duration so it can be considered as a treatment of choice.