Purpose: The present study was conducted to evaluate serum interleukin-10 and MMP-9 levels as predictors of glycemic alteration in type 2 Diabetic patients with periodontitis. Subjects and methods: This study was conducted on thirty (30) patients that were divided into two groups: Group 1 fifteen (15) patients with type 2 diabetes and periodontitis; Group 2 fifteen (15) patients with type 2 diabetes and c periodontitis receiving adjunctive treatment Omega-3 and aspirin. Elisa kit was used to evaluate the concentration of serum Mmp-9 and IL-10. Results: There was a statistically significant difference between (Group 1) and (Group 2) in the serum level of Mmp-9 (P-value 0.028) (P-value 0.010) after 3m and 6m as well as the serum level of IL-10(P-value 0.020) (P-value 0.029). Conclusion: Serum IL-10 can be used as predictor of glycemic alteration in type 2 Diabetes Mellitus.Omega-3 can be used as adjunctive treatment in periodontal disease.