Purpose: The aim of this randomized controlled clinical trial was the evaluation of alveolar ridge preservation using a composite of bioactive glass and platelet rich fibrin either alone or combined with melatonin in chronic periodontitis patients. This aim was fulfilled through: Clinical assessment and radiographic assessment. Subjects and Methods: A total of thirty extraction sockets in 29 patients were randomly divided into three groups; control group treated by atraumatic extraction alone, test1 group (application of bioactive glass mixed with PRF) and test 2 group (application of bioactive glass mixed with PRF and melatonin gel). The clinical parameters recorded at baseline, 3 months and 6 months after treatment. Cone beam tomography radiographs used to measure width of socket at base line and 6months post operatively. Results: By clinical assessment both group II and group III showed significant increase in length and width of alveolar ridge with significant difference between the two groups in the whole study period. Radiographically; both group II and group III showed a significant increase in all parameters by time, while control group, there was a significant decrease at the end of the study period. Conclusion: Within the limits of this study: The composite use of bioglass, Prf & melatonin in group III reflected the best clinical, and radiographic results.