Purpose: The goal of this study was to evaluate the clinical effect of propolis gel associated with non surgical therapy in the management of chronic periodontitis. Subjects and Methods: Thirty chronic periodontitis patients were selected in this study with probing depth not less than 5 mm in each site. Patients randomly divided into three groups ten subjects on each. Patients in Group1 were treated with scaling and root planning and local delivery of propolis gel with chitosan polymer. Patients in group 2 were treated with non surgical therapy and propolis gel with polyox polymer. Patients in group 3 were treated with non surgical therapy alone. The clinical parameters were assessed at baseline, 1 month and 3 months. Results: Clinical parameters showed a favorable improvement in group received propolis gel with polyox polymer than the group received propolis gel containing chitosan polymer. Conclusion: Adjunctive use of propolis with polyox polymer to non surgical therapy showed favorable results over use of propolis with chitosan polymer in patients with chronic periodontitis.