Purpose: This study was conducted to determine clinical effect of local application of hyaluronan gel alone or with platelet rich fibrin (PRF) in intrabony defects. Material and Methods sixteen patients with chronic periodontitis with twenty intrabony defects (probing depth ≥ 5 m m) were included in this study. Following scaling and root planing and re-evaluation, defects were divided to mucoperiosteal flap with 0.8 percent of hyaluronan gel (test) or platelet rich fibrin (test) or combination of both (test) or mucoperiosteal flap only (control). Clinical attachment level (CAL), probing pocket depth -for short- ( PPD ), gingival index (GI) and plaque index (PI) were taken at baseline,3 and 6 months. Results: clinical improvement was noticed statistically in each group through different intervals . nevertheless, non significant difference had been reported upon comparing different groups regarding percent change in GI,PPD and CAl. Conclusion: The local application of hyaluronan gel alone improve the clinical outcomes more than open flap debridment.However, hyaluronan gel with PRF in managing perio-dontal intrabony defects did not showed additional benefits.