Purpose: This study was designed to evaluate and compare the efficiency of piezoelectric device for implant site preparation clinically and radiographically. Materials and methods: The study included 12 patients divided into two groups. The group A received implants prepared with the conventional drills (CDs), while, group B, the piezoelectric devices (PEDs) were used. The stability of implant was measured, immediately, at 2 months, and 4 months after the implant insertion. Also, the drilling time was recorded. While, the Marginal bone loss (MBL) and Bone mineral density (BMD) were recorded immediately, at 3, and 6 months after implant insertion. Results: Group B had a significant higher ISQ values all over the follow up periods. The drilling time of ISP was significantly higher in group B. Regarding the MBL, there was no a statistical significant difference. The BMD increased significantly in group B immediately, and at 3 month. Conclusion: The osseointegration of implants prepared with PED was significantly greater than that of implants which prepared with the CDs all over the time points, but the PEDs need significantly longer surgical time than the CDs