ABSTRACT
Purpose: This study was aimed to define the effect of nonsurgical periodontal therapy on chronic periodontitis in chronic kidney disease patients and healthy patients by detection of prohepcidin level in the blood. Materials and methods: The study included 20 chronic periodontitis patients that were divided into:-Group I included 10 patients with chronic kidney disease; Group II which involved 10 healthy patients . Chronic periodontitis was defined through probing pocket depth and by clinical attachment level. All clinical and biochemical parameters were evaluated afterward 3 months of non-surgical periodontal cure. Results: The improvement in clinical parameters showed the efficacy of NSPT in both groups. The periodontal therapy was the cause to reduce prohepcidin level in both groups and a higher reduction in CKD group in comparison to control group at baseline and after 3 months. Conclusion: By reduction in serum prohepcidin and systemic inflammatory response, nonsurgical periodontal treatment has proved to be an effective method to control inflammation seen in patients with CKD.