Purpose: This study was designed to assess the impact of irrigating solutions on push out bond strength of Bio- ceramic and Resin Based Endodontic Sealers. Materials and Methods: sixty extracted human teeth with straight single root and canal were prepared with RACE FKG rotary files till size 35 taper 06. The samples were dispensed into two experimental groups according to root canal sealer used (30 samples each). group1 Total Fill Bio-ceramic sealer after irrigation with, and Group 2: AH Plus sealer. The specimens were further randomly divided into two sub groups (15 samples each) according to the final irrigation solution applied. Group (a): irrigated with 17%EDTA, Group (b): irrigated with 2% CHX. The samples were obturated by single cone gutta-percha with vertical condensation technique. Results: regarding the groups. The type of irrigating solution affects the bond strength of total fill bio ceramic sealer. Final irrigation with EDTA result the highest bond strength of bio ceramic sealer to root dentine which was scientifically different from irrigation with CHX. Bond strength values was as follows: EDTA>CHX. Conclusion: the type of final irrigation affects the adhesion of total fill bio ceramic and AH plus sealers to root canal dentine