Purpose : This randomized split mouth study was designed assessing complete root coverage (CRC) in treating gingival recession Miller class I and II site defects with minimal invasive surgical approach in the esthetic zone using MCAT in conjugation with SCTG alone or soaked in 0.1 % melatonin gel .Method and Materials: six healthy patients (6 females) of total 22 Miller Class I, II site defect were treated with MCAT combined with SCTG alone (control group) and with MCAT in combined SCTG soaked with 0.1% melatonin gel (test group). Measurements of clinical parameters (CAL,RD,RW,KTW,PI) was evaluated before surgery and at 6 months after surgery. The primary objective was complete root coverage (CRC). Gingival crevicular fluid sampled and analyzed for anti-oxidative stress marker the GCF protein carbonyl (PC) before surgery, 2 days, 2 weeks and 3 months postoperatively.Results: Healing was uneventful in all cases without any complications. 6 months post surgery CRC and other soft tissue clinical parameters were obtained in all patients within each group whereas, no statistically significant difference between the studied groups .CRC for control group was 58.3%, whereas for test group was 60%. .Conclusion: The current findings found the treatment modality results in predictable coverage of Miller Class I and II site defects. The influence of melatonin addition to SCTG on clinical parameters, although non- significant