Purpose: The purpose of the current study was to evaluate marginal accuracy and color stability of lithium disilicate laminate veneer compared to hybrid ceramic veneer. Materials and Methods: Forty maxillary teeth were collected and prepared (but joint preparation) to receive a laminate veneer. They were equally sub grouped (n= 20) to receive 2 types of laminate veneers (IPS E-max CAD and vita enamic). The veneer was milled from the blocks in a CEREC 3 Machine. All veneers were cemented with resin cement. All samples had been subjected to 20000 thermal cycles which are equivalent twenty years of clinical use. Marginal gap were measured by using universal serial bus (USB) Digital microscope. Colors were measured using a reflective spectrophotometer. Marginal gap and color were measured pre and post thermo cycles. Data were tabulated and statistically analyzed. Results: For the marginal gap, the two tested materials demonstrated an acceptable value. Regarding the color stability there was color change for both groups after thermal cycling with higher mean values for Vita Enamic than E-max and that was statistically insignificant. Conclusion: The E-max veneers recorded less marginal accuracy and more color stability than Vita Enamic and they did not affected by thermo cycling.