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17185

Potential Effect of Alendronate on Tooth Eruption and Molar Root Formation in Young Growing and Osteoprotic Albino Rats (A Histological and Histochemical Study)

Article

Last updated: 03 Jan 2025

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Tags

Oral and Dental Biology

Abstract

Aim: The aim of the present study to evaluate the potential effect of Sodium Alendronate on tooth eruption and root formation in young growing and osteoporotic albino rats .   Materials and Methods Sixty newborn wister albino rats with their average weight 6 grams, each were used in the study. Rats were divided into 4 groups (groupI, groupII, group III &group IV) : GI negative control, GII positive control, GIII Alendronat treated group, GIV (alendronate + dexamethasone) then each group was divided into 3 subgroups according to the date   of scarification at7,14,30 days. Rats were subjected to subcutaneous injection of sodium alendronate and dexamethasone in their dorsal back. The specimens were processed for histological and histochemical analysis. Results: alendronate prevented tooth eruption and root formation but dexamethasone caused resorption of bone over developing molar but didn't affect molar eruption and root formation.   Conclusion: sodium alendronate caused increase in bone formation and obstructed eruption pathway. Sodium alendronate prevented maturation of alveolar bone while dexamethasone caused destruction of alveolar bone but didn't affect normal tooth eruption.

DOI

10.21608/adjg.2018.17185

Keywords

Sodium alendronate, dexamethasone, tooth eruption, root formation

Authors

First Name

Somaya

Last Name

Salwat

MiddleName

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Affiliation

Demonstrator of Oral and Dental Biology, Faculty of Dental Medicine for Girls , Al- Azhar University.

Email

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City

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Orcid

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First Name

Mona

Last Name

Farid

MiddleName

-

Affiliation

Professor and Head of Oral and Dental Biology Department, the Former Dean of Faculty of Dental Medicine for Girls, Al- Azhar University.

Email

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City

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Orcid

-

First Name

Heba

Last Name

Hakam

MiddleName

-

Affiliation

Assistant Professor of Oral and Dental Biology, Faculty of Dental Medicine for Girls, Al- Cairo University.

Email

-

City

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Orcid

-

Volume

5

Article Issue

3

Related Issue

3615

Issue Date

2018-07-01

Receive Date

2018-10-21

Publish Date

2018-07-01

Page Start

237

Page End

242

Print ISSN

2537-0308

Online ISSN

2537-0316

Article File

ADJG_Volume 5_Issue 3_Pages 237-242.pdf

PDF . 389.8kB

Link

https://adjg.journals.ekb.eg/article_17185.html

Detail API

https://adjg.journals.ekb.eg/service?article_code=17185

Order

3

Type

Original Article

Type Code

488

Publication Type

Journal

Publication Title

Al-Azhar Dental Journal for Girls

Publication Link

https://adjg.journals.ekb.eg/

MainTitle

Potential Effect of Alendronate on Tooth Eruption and Molar Root Formation in Young Growing and Osteoprotic Albino Rats (A Histological and Histochemical Study)

Details

Type

Article

Created At

22 Jan 2023