Objective: to evaluate and compare the efficacy of two different toothpaste (parodontax and Dr. John's formula gel) on the degree of gingivitis during fixed orthodontic treatment.Material and Methods: A sample of 30 patients with an age range of 13-22 years, requiring fixed orthodontic treatment were evaluated for the efficacy of two types of toothpaste after inatiation of gingivitis, i.e, Dr.Jhon's formula (groupI), Parodontax (groupII), and Signal (groupIII). At baseline, onset of gingivitis and (1-3-6 weeks) from using the toothpaste, clinical parameters and resistin samples from gingival crevicular
fluid(GCF) were assessed from the patients in all groups. Gingival crevicular fluide samples of resistin were detected by enzyme-linked immunosorbent assay. Results: the greatest mean value of resistin concentration was recorded at onset of gingivitis, there was no significant difference between groups, 6 weeks after treatment group II revealed a significant lower value compared to group I&III , and the greatest mean value of clinical parameters Plaque Index (PD), Probing Depth (PI), and Gingival Index (GI) were recorded at onset of gingivitis, 6 weeks after treatment group I revealed a significant lower value in PI compared to group II&III and group II revealed a significant lower value in PD and GI compared to group I& III. Conclusion: the results revealed that, the two studied Toothpaste significantly reduced gingivitis during orthodontic treatment compared to the control, Dr. Jhone's toothpaste has significant decrease in Plaque
Index over the parodontax toothpaste, and Parodontax toothpaste provided obvious significant decrease in the Gingival Bleeding and Probing Depth compared to Dr.Jhon's formula toothpaste.