Aim: The aim of the present study was to evaluate the effect of demineralized human dentin matrix graft alone and when combined with statin and propolis on bone repair in bone defects in the tibia of rabbits histologically. Materials and Methods Fifteen adult male rabbits (weight 2 to 2.5 kg) were used in this study. In each rabbit four holes were created (two in each tibia), one was left empty as control, the second was packed with DDM slices, the third was packed with DDM slices saturated with statin and the last one was packed with DDM mixed with propolis. The animals were sacrificed at 2, 4 and 6 weeks postoperatively and the bone specimens were processed for histological analysis. Results: There was a significant increase in the newly formed bone tissue in DHDM and DHDM/statin groups and the DHDM/statin group presented excellent organization of the formed bone. Conclusion: The DHDM was biocompatible with the bone repair and stimulated bone tissue formation. Addition of statin markedly accelerated the bone repair while propolis caused delay in the early stages of repair.