Objective: The purpose of this study is to 1) evaluate clinically and radiographically the carious dentin treated with Ozone, Casein Phosphopeptide - Amorphous Calcium Phosphate (Tooth Mousse) mixed with Glass Ionomer and Glass Ionomer Cement only in primary molars of 4 - 8 years old children (In vivo study), and 2) Compare the micro
hardness of carious dentin treated with Ozone, Casein Phosphopeptide - Amorphous Calcium Phosphate (Tooth Mousse) mixed with Glass Ionomer and Glass Ionomer Cement only in extracted primary molars (In vitro study). Design: Forty five primary molars with proximal caries in children, ranging in their age from 4-8 years old. They were equally divided into three groups (15 each) according to the materials were used for restoration. The first group was restored with glass ionomer cement, the second group was restored with Casein Phosphopeptide – Amorphous Calcium Phosphate
(CPP-ACP ) incorporated with glass ionomer cement, and the third group was pretreated with ozonized olive oil then restored with glass ionomer cement. Also this study was carried out on forty five freshly extracted carious primary molars, which divided equally into three groups and restored as mentioned before in clinical cases and examined
for microhardness assessment. Results: the greatest value of mean radiodensity was recorded in Tooth Mousse group followed by Glass ionomer group then Ozone group. However there was no statistically significant difference between the three groups. Conclusion: Casein phosphopeptide - Amorphous Calcium Phosphate (Tooth Mousse) mixed with Glass ionomer cement as well as glass ionomer alone seemed to be successful as a remineralizing agent in primary molars.