Objective: The aim of this study is to investigate histological the effect of power horse energy drink intake with different doses on the submandibular salivary glands of albino rats. The possible modulated recovery of expected adverse effects from the different doses of the taken power horse energy drink. Materials and Methods: Sixty five adult male albino rats (weighing 180-200 grams) were divided equally into seven groups. Group I (control), group (IIA,IIIA&IVA) which received a daily different dose power horse energy drink using an oro-pharyngeal metallic curved tube for 8 weeks then sacrified and group(IIB,IIIB&IVB)which left alive with stoppage of beverage intake for another 4 weeks for recovery then scarification were done. The specimen were stained by H&E. Result: Power horse energy drink intake result in adverse effects on the submandibular salivary glands in the form of structural changes of all gland elements including: These changes are dose dependant and showed in the following:Atrophy of secretory units, loss of normal glandular architecture, numerous signs of degeneration and premalignant changes. Signs of degeneration of striated.