Increasing of the electronic waste all over the world is related to the rapid growing of information and communication technology. Electronic waste contains highly toxic substances and improper handling for this kind of waste will cause several impacts on human health and environment. Management of electronic waste is still in its initial phase in different developing countries. Aim of the study: Absence of specific guideline and strategy about managing of electronic waste inside different enterprises leads to develop an evidence-based integrated environmental system for management of electronic waste by using an Evidence Based Practice (EBP) methodology. This integrated system covers all aspects related to the management of electronic waste This system can be used as a guideline by the officials and responsible staff in different enterprises for managing of electronic waste in proper manner to safeguard the human health and environment from the negative impacts that generated from electronic waste.