Background & Objectives:
Androgen receptor (AR) is recently one of the most studied biomarkers in breast cancer, having a role in the genesis and development of breast cancer. The current study aims to detect the expression of AR in one hundred females, stage IIB and stage III, hormonal positive Her-2neu negative breast cancer patients and to relate its expression with overall survival (OS) and disease free survival (DFS) using histoscore (median H score).
Methods:
Histological tissue from breast tumors was examined by immunohistochemistry for AR expression and median H score was calculated.
Results:
Of 100 female with hormonal positive, Her2neu negative breast cancer cases identified, 19 cases (19%) were AR negative and 81 cases (81%) were positive AR. Using median H score, it was found that patients with earlier stage, lower histological grade and negativity for lymphovascular invasion had higher median H score (>120) reaching statistical significance.
Conclusion:
Our study revealed no statistical significant association between AR higher expression (H score>120) and OS or DFS compared to AR lower expression (median H score≤120). However, work on this special group (stage IIB and stage III, hormonal positive Her-2neu negative) using larger number of patient is recommended.