bladder cancer is a major oncological problem; it has a high incidence rate with high mortality. Two pathological types are detected in bladder cancer: urothelial and non-urothelial. In Egypt; it was the first common malignancy in males but now it is the second after hepatocellular carcinoma, with the highest mortality worldwide. The two main histopathological types in Egypt are transitional cell carcinoma and squamous cell carcinoma. Treatment of bladder cancer has limited options and poor response. 5-year survival in metastatic bladder cancer is 5%. Studies are ongoing trying to find a new drug that can improve disease outcomes. Our study evaluates the expression of Estrogen receptor Beta in bladder cancer and study the association with the clinicopatological factors.