Introduction: Chronic lymphocytic leukemia (CLL) is considered the most common type of leukemia in the western world and in Egypt CLL is the most common subtype of leukemia's. The National Cancer Registry reported over 80% of lymphoid leukemia's are CLL. Chronic lymphocytic leukemia (CLL) is characterized by heterogeneous clinical course. Therefore, the identification of prognostic and predictive factors for CLL is critical and this is a field of active investigation. Over the past several years, a group of so-called new prognostic factors has been developed. This several prognostic factors associated with the immunophenotypic profile, cytogenetic features and mutational status of the immunoglobulin heavy chain (IGVH). Aim of the work: The aim of this review is to discuss the prognostic role of both CD49d and trisomy12 in chronic lymphocytic leukemia (CLL). Conclusion: Combination of CD49d and trisomy12 may have very strong prognostic roles in the prognosis of CLL and add a prognostic value to CLL patients.