Stromal CD10 immunohistochemical expression in urothelial carcinoma of urinary bladder and correlation with clinicopathological parameters - Egyptian Knowledge Bank

10540

Stromal CD10 immunohistochemical expression in urothelial carcinoma of urinary bladder and correlation with clinicopathological parameters

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Last updated: 03 Jan 2025

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Abstract

CD10 is widely expressed in various tumor types and their surrounding cancer associated fibroblasts; and correlate with
poor prognosis. In present study CD10 immunohistochemical expression in stromal fibroblasts surrounding urothelial
carcinoma and its relationship with clinicopathological parameters were investigated.
Patients and Methods: Formalin-fixed paraffin embedded tissue sections from 106 urothelial cancer specimens were
stained with CD10 antibody using immunohistochemistry technique. Expression of CD10 in the stromal cells was then
analysed to evaluate its association with different clinicopathological variables.
Results: Stromal CD10 expression was significantly associated with each of high grade (P<0.001), invasive tumor,
advanced stage (P<0.001), squamous differentiation of tumor cells (P=0.02) and papillary architecture (P<0.001). There
was no significant association between stromal CD10 expression and, and patient age, sex and tumor size.
Conclusion: Increased expression of CD10 in cancer associated fibroblasts was strongly correlated with tumor
progression and invasion

DOI

10.21608/secioj.2017.10540

Keywords

CD10, stroma, urothelial, stage, Grade, Papillary, Bilharziasis

Volume

Article Issue

Related Issue

2045

Issue Date

2017-10-01

Receive Date

2017-09-24

Publish Date

2017-10-01

Page Start

Page End

Print ISSN

2537-0995

Online ISSN

2314-8500

Article File

SECIOJ_Volume 5_Issue 4_Pages 48-57.pdf

PDF . 615.2kB

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https://secioj.journals.ekb.eg/article_10540.html

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https://secioj.journals.ekb.eg/service?article_code=10540

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Publication Type

Journal

Publication Title

SECI Oncology Journal

Publication Link

https://secioj.journals.ekb.eg/

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