Beta
ManageSearchChatDiscover
5682

Study of different genotypes of Vitamin-D Receptor (VDR) Gene Polymorphisms in Patients Eligible for Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) from a Sibling

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Vitamin-D receptor (VDR) is found in both normal and neoplastic hemopoietic cells, and VDR gene
polymorphism may play an important role in the clinical outcome of HLA-matched sibling donor allogeneic
hematopoietic stem cell transplantation (allo-HSCT). The distribution of the genotypes in a given population would
affect the impact of the polymorphism in different conditions including the clinical outcome of HSCT.
Objectives: to study the different genotypes of VDR polymorphisms in patients eligible for sibling donor alloHSCT.
Patients and methods: Eighty-one patients undergoing allo-HSCT and their HLA-identical sibling donors were
examined using polymerase chain reaction for restriction fragment length polymorphism (PCR-RFLP) analysis for
FokI (rs10735810), ApaI (rs7975232) and TaqI (rs731236) polymorphisms.
Results: Patients' genotype frequencies of the three VDR polymorphisms were as follows: for FokI: Heterozygous
(H) 76/78 (97.4%), mutant (M) 1/78 (1.3%) and wild (W) 1/78 (1.3%); for ApaI: (H) 26/72 (36.1%), (M) 7/72
(9.7%), and (W) 39/72 (54.2%); for TaqI: (H) 37/68 (54.4%) and (W) 31/68 (45.6%). While donors' genotype
frequencies were as follows: for FokI: (W) 40/75 (53.4%), (H) 28/75 (37.3%) and (M) 7/75 (9.3%); for ApaI: (W)
31/66 (47.0%), (H) 28/66 (42.4%) and (M) 7/66 (10.6%); for TaqI: (W) 26/65 (40.0%), (H) 38/65 (58.5%) and (M)
1/65 (1.5%).
Conclusion: The genotype frequencies of VDR polymorphisms in our population were different from that of
Caucasians and Asian countries, and this variability of distribution could explain that there is ethnic variability in
vitamin D receptor gene polymorphisms.

DOI

10.21608/secioj.2016.5682

Keywords

Vitamin-D Receptor (VDR), FokI (rs10735810), ApaI (rs7975232), TaqI (rs731236), hematopoietic stem cell transplantation (HSCT)

Volume

4

Article Issue

3

Related Issue

991

Issue Date

2016-07-01

Receive Date

2016-07-01

Publish Date

2016-07-20

Page Start

35

Page End

39

Print ISSN

2537-0995

Online ISSN

2314-8500

Article File

SECIOJ_Volume 4_Issue 3_Pages 35-39.pdf

PDF . 184.6kB

Link

https://secioj.journals.ekb.eg/article_5682.html

Detail API

https://secioj.journals.ekb.eg/service?article_code=5682

Order

1

Type

Original Article

Type Code

468

Publication Type

Journal

Publication Title

SECI Oncology Journal

Publication Link

https://secioj.journals.ekb.eg/

MainTitle

Study of different genotypes of Vitamin-D Receptor (VDR) Gene Polymorphisms in Patients Eligible for Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) from a Sibling Donor

Details

Type

Article

Created At

22 Jan 2023