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ERCC1, as Prognostic and Predictive Marker in Metastatic Colorectal Cancer Patients Treated with Oxaliplatin based Chemotherapy

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Last updated: 03 Jan 2025

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Abstract

Background and objectives: Excision repair cross-complementation group 1 gene (ERCC1) encodes an enzyme
that is essential for the efficient repair of DNA damage induced by platinum compounds such as Oxaliplatin agent.
Our study investigated the association between ERCC1 protein expression and clinical outcomes of metastatic
colorectal cancer (CRC) patients administrated with combination Oxaliplatin (OX) and 5-fluorouracil (5-FU)
treatment.
Patients and methods: Immunohistochemistry (IHC) analysis of the expression of ERCC1 protein was performed
on tumor tissue of 30 patients with metastatic CRC, who received first line Oxaliplatin /5-fluorouracil treatment.
Tumor response, progression free survival (PFS) and overall survival (OS) were evaluated.
Results: there was no significant association between ERCC1 expression and response to chemotherapy (p=0.880)
or PFS (p=0.133) was observed, however patients negative for ERCC1 expression had a better OS than those
positive for ERCC1 (p=0.043).
Conclusion: ERCC-1 expression is a good prognostic marker in patients with metastatic CRC who were treated
with Oxaliplatin/5-fluorouracil, but may not be useful for the prediction of chemotherapeutic response in these
patients.

DOI

10.21608/secioj.2016.5672

Keywords

ERCC1, metastatic CRC, Oxaliplatin, Survival, tumor response, prognostic marker, predictive marker, IHC

Volume

4

Article Issue

1

Related Issue

989

Issue Date

2016-03-01

Receive Date

2016-01-01

Publish Date

2016-01-10

Page Start

1

Page End

6

Print ISSN

2537-0995

Online ISSN

2314-8500

Article File

SECIOJ_Volume 4_Issue 1_Pages 1-6.pdf

PDF . 481.8kB

Link

https://secioj.journals.ekb.eg/article_5672.html

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https://secioj.journals.ekb.eg/service?article_code=5672

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Original Article

Type Code

468

Publication Type

Journal

Publication Title

SECI Oncology Journal

Publication Link

https://secioj.journals.ekb.eg/

MainTitle

ERCC1, as Prognostic and Predictive Marker in Metastatic Colorectal Cancer Patients Treated with Oxaliplatin based Chemotherapy

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Article

Created At

22 Jan 2023