Objective: Evaluation of the antioxidant protective role of beetroot and apple to reduce the impact of ionizing radiation on the blood components. Subjects and Methods: Sixty adult white male rats were evenly divided into four experimental groups, Group 1 (n= 15) was used as a control group. Groups 2, 3, and 4 (n=15 each) were injected intravenously with radioactive material Tc-99m 130 ± 5 Mega Becquerel )MBq( (5 ± 0.5 Micro Curry )mCi)( as a source of ionizing radiation (gamma rays). Groups 2 and 4 were fed with apple fruit and beet seeds in addition to a small amount of commercial food. Rats in G3 were fed with commercial food pellets only and received the same volume of water. Rats in groups G1, G2, and G3 were sacrificed after7 days while those of G4 were sacrificed after 30 days. Osmotic fragility of RBCs and hematological parameters were investigated for each group. The structure characteristics of the blood cells for all groups were studied by recording the UV -Vis spectra. Results: The study revealed statistically significant changes regarding RBCs indices along with increased osmotic fragility among rats of group 3 compared to those in groups 1, 2, and 4. The U.V. spectrum revealed a partial irregularity in the RBCs. Conclusion: Our study pointed out the protective role of natural products namely, beetroots and green apple extracts, against the adverse impact of ionizing radiation on blood indices.